Spectroscopy-Driven Estimation for Continuous Antibody Manufacturing
Continuous biomanufacturing runs nonstop, so operators need to know protein concentrations as the process runs, not hours later from an offline sample. My M.A.Sc. thesis combines inline UV and Raman spectroscopy with multivariate modelling (PCA/PLS) and mechanistic state estimation to infer concentration in real time across a continuous monoclonal antibody process. That is the foundation for tighter monitoring, process analytical technology (PAT), and advanced control.
Current research · Dr. P. Mhaskar